Angiotensin-Converting Enzyme 2 Potentiates SARS-CoV-2 Infection by Antagonizing Type I Interferon Induction and Its Down-Stream Signaling Pathway
ABSTRACT The innate interferon (IFN) response constitutes the first line of host defense against viral infections.It has been shown that IFN-I/III treatment could effectively contain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro.However, how SARS-CoV-2 survives through the innate antiviral mechanism remains to be